If you wanted to get rich, how would you do it? I think your best bet would be to start or join a startup. That’s been a reliable way to get rich for hundreds of years. The word “startup” dates from the 1960s, but what happens in one is very similar to the venture-backed trading voyages of the Middle Ages.
Up second, Ian Landsman writes an interesting piece on 4 Rules for the Practical Entrepreneur. I’m not sure I agree with all of Ian’s points, perhaps I’m not the practical entrepreneur that he discusses, but the advice is good. Preferring B2B over B2C sounds rather like a personal preference (and has its own challenges, as mentioned in the comments), but each to his own.